ELISA/assay

Human Anthrax Protective Antigen IgG ELISA Kit

MBS008610

96 Strip Wells

600 USD

ELISA Kit

Human Anthrax Protective Antigen IgG ELISA Kit

Anthrax Protective Antigen IgG

toll-like receptor 9; Toll-like receptor 9; toll-like receptor 9; toll-like receptor 9

APA IgG

TLR9; TLR9; CD289

TLR9_HUMAN

Human

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

8394456

NP_059138.1

NM_017442.3

Q9NR96

115,860 Da

African Trypanosomiasis Pathway 194384!!African Trypanosomiasis Pathway 194323!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!IGF1R Signaling Cascade Pathway 730346!!IRS-mediated Signalling Pathway 106426!!IRS-related Events Pathway 106424!!IRS-related Events Triggered By IGF1R Pathway 730348

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]

Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Ref.10 Ref.11. Subunit structure: Interacts with MYD88 via their respective TIR domains . By similarity. Interacts (via transmembrane domain) with UNC93B1 . By similarity. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses . By similarity. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Ref.11 Ref.12. Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein . By similarity. Endosome . By similarity. Lysosome . By similarity. Cytoplasmic vesicle phagosome . By similarity. Note: Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist . By similarity. Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. Sequence similarities: Belongs to the Toll-like receptor family.Contains 26 LRR (leucine-rich) repeats.Contains 1 TIR domain.

96 Strip Wells

600 USD