ELISA/assay

Human Apolipoprotein C2 Precursor ELISA Kit

MBS008337

96 Strip Wells

600 USD

ELISA Kit

Human Apolipoprotein C2 Precursor ELISA Kit

Apolipoprotein C2 Precursor

apolipoprotein C-II; Apolipoprotein C-II; apolipoprotein C-II; apolipoprotein C2; apolipoprotein C-II; Apolipoprotein C2

PRE-APO-C2

APOC2; APOC2; APO-CII; APOC-II; APC2; Apo-CII; ApoC-II

APOC2_HUMAN

Human

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

32130518

NP_000474.2

NM_000483.4

P02655

11,284 Da

Chylomicron-mediated Lipid Transport Pathway 106157!!Disease Pathway 530764!!Diseases Associated With Visual Transduction Pathway 771581!!HDL-mediated Lipid Transport Pathway 106158!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Lipoprotein Metabolism Pathway 106156!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Retinoid Metabolism And Transport Pathway 187208!!Signal Transduction Pathway 477114

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Subcellular location: Secreted. Tissue specificity: Secreted in plasma. Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23. Sequence similarities: Belongs to the apolipoprotein C2 family.

96 Strip Wells

600 USD