ELISA/assay

Rat Sex Determining Region Y Box Protein 3 ELISA Kit

MBS008199

48-Strip-Wells

435 USD

ELISA Kit

Rat Sex Determining Region Y Box Protein 3 ELISA Kit

Sex Determining Region Y Box Protein 3

SOX3; Transcription factor SOX-3

SOX3

SOX3

SOX3_HUMAN

Rat

Store all reagents at 2-8 degree C

Assay Type: Sandwich

530020

CAA50465.1

P41225

45,210 Da

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. [provided by RefSeq, Jul 2008]

SOX3: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Defects in SOX3 are a cause of panhypopituitarism X- linked (PHPX). Affected individuals have absent infundibulum, anterior pituitary hypoplasia, and ectopic posterior pituitary. Defects in SOX3 are the cause of mental retardation X- linked with isolated growth hormone deficiency (MRXGH). Defects in SOX3 are the cause of 46,XX sex reversal type 3 (SRXX3). A condition in which male gonads develop in a genetic female (female to male sex reversal). Copy number variations (CNV) encompassing or in close proximity to SOX3 are responsible for XX male reversal. These variations include two duplications of approximately 123 kb and 85 kb, the former of which spans the entire SOX3 gene; a 343 kb deletion immediately upstream of SOX3 that is probably responsible of altered regulation (and not increased dosage) of SOX3; a large (approximately 6 Mb) duplication that encompasses SOX3 and at least 18 additional distally located genes. Its proximal breakpoint falls within the SOX3 regulatory region. This large rearrangement has been found in a patient with XX male reversal and a complex phenotype that also includes a scrotal hypoplasia, microcephaly, developmental delay, and growth retardation. Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: Xq27.1. Cellular Component: nucleus. Molecular Function: DNA binding; transcription factor activity. Biological Process: sex determination; negative regulation of neuron differentiation; spermatid differentiation; hypothalamus development; organ morphogenesis; central nervous system development; sensory organ development; transcription, DNA-dependent; pituitary gland development; neuron development; negative regulation of transcription from RNA polymerase II promoter; Sertoli cell development. Disease: Panhypopituitarism, X-linked; Mental Retardation, X-linked, With Panhypopituitarism

48-Strip-Wells

435 USD

96-Strip-Wells

600