catalog number :
MBS008154
products type :
ELISA Kit
products full name :
Hamster Polymorphonuclear Elastase ELISA Kit
products short name :
Polymorphonuclear Elastase
other names :
PREDICTED: tubulin-specific chaperone E isoform X3; Tubulin-specific chaperone E; tubulin-specific chaperone E; tubulin-folding cofactor E; progressive motor neuropathy; tubulin-specific chaperone E; Tubulin-folding cofactor E
other gene names :
Tbce; Tbce; pmn; 2610206D02Rik; C530005D02Rik
uniprot entry name :
TBCE_MOUSE
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma, Cell Culture Supernatants, Tissue Homogenate, Urine and other Body Fluids. Detection Range: 6.25 ng/ml ~ 200 ng/ml. Sensitivity: Typically less than 1.0 ng/ml.
other info2 :
Intended Uses: This ELISA kit is intended for laboratory in vitro research use only, not for drug, household or other use! The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm by a spectrophotometer. In order to measure the concentration of Hamster PMN in the specimen, this ELISA kit includes a set of calibration standards. The calibration standards are assayed at the same time as the specimens and allow the operator to produce a standard curve of Optical Density versus Hamster PMN concentration. The concentration of Hamster PMN in the specimens is then determined by comparing the O.D. of the specimens to the standard curve.
ncbi acc num :
XP_006516838.1
ncbi gb acc num :
XM_006516775.1
ncbi mol weight :
59,086 Da
ncbi pathways :
Metabolism Of Proteins Pathway (970583); Post-chaperonin Tubulin Folding Pathway (1000372); Protein Folding Pathway (1000365)
ncbi summary :
This gene encodes a tubulin binding cofactor that participates in microtubule dynamics. A mouse model of progressive motor neuropathy (pmn) was discovered to harbor a single amino acid deletion in this gene. Mice that are homozygous for pmn allele exhibit progressive atrophy and premature death due to respiratory failure. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
uniprot summary :
TBCE: Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. Defects in TBCE are a cause of hypoparathyroidism- retardation-dysmorphism syndrome (HRD); also known as hypoparathyroidism with short stature, mental retardation, and seizures or Sanjad-Sakati syndrome. HRD is an autosomal recessive disorder reported almost exclusively in Middle Eastern populations. Defects in TBCE are the cause of Kenny-Caffey syndrome type 1 (KCS1). KCS1 is similar to HRD with the additional features of osteosclerosis and recurrent bacterial infections. Belongs to the TBCE family. Protein type: Chaperone. Cellular Component: cytoskeleton; cytoplasm. Molecular Function: unfolded protein binding. Biological Process: tubulin folding; developmental growth; axonogenesis; protein folding; adult locomotory behavior; muscle atrophy; microtubule cytoskeleton organization and biogenesis; post-chaperonin tubulin folding pathway; peripheral nervous system neuron axonogenesis; post-embryonic development