Monkey Transthyretin (TTR) ELISA Kit | MyBioSource MBS007983 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Monkey Transthyretin (TTR) ELISA Kit

catalog :

MBS007983

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS007983

products type :

ELISA Kit

products full name :

Monkey Transthyretin (TTR) ELISA Kit

products short name :

[Transthyretin (TTR)]

other names :

[transthyretin; Transthyretin; transthyretin; transthyretin; ATTR; Prealbumin; TBPA]

products gene name :

[TTR]

other gene names :

[TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB]

uniprot entry name :

TTHY_HUMAN

reactivity :

Monkey

sequence length :

147

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Rat Body Fluids, Tissue Homogenates, Secretions Or Feces Samples. Assay Type: Quantitative Sandwich. Detection Range: 25nmol/L-200nmol/L. Sensitivity: 1.0nmol/L.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TT4 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

4507725

ncbi acc num :

NP_000362.1

ncbi gb acc num :

NM_000371.3

ncbi mol weight :

15,887 Da

ncbi pathways :

Amyloid Fiber Formation Pathway (1269169); Disease Pathway (1268854); Diseases Associated With Visual Transduction Pathway (1268929); Diseases Of Signal Transduction Pathway (1268855); Extracellular Matrix Organization Pathway (1270244); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Metabolism Pathway (1269956); Metabolism Of Fat-soluble Vitamins Pathway (1339147); Metabolism Of Proteins Pathway (1268677); Metabolism Of Vitamins And Cofactors Pathway (1270144)

ncbi summary :

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

uniprot summary :

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: extracellular region; extracellular space. Molecular Function: identical protein binding; protein binding. Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; retinoid metabolic process. Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095