ELISA/assay

Goat A Disintegrin and Metalloprotease 9 ELISA Kit

MBS007971

96 Strip Wells

600 USD

ELISA Kit

Goat A Disintegrin and Metalloprotease 9 ELISA Kit

A Disintegrin and Metalloprotease 9

ADAM9 protein; Disintegrin and metalloproteinase domain-containing protein 9; disintegrin and metalloproteinase domain-containing protein 9; cone rod dystrophy 9; myeloma cell metalloproteinase; cellular disintegrin-related protein; ADAM metallopeptidase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9; ADAM metallopeptidase domain 9; Cellular disintegrin-related protein; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase

ADAM9

ADAM9; ADAM9; MCMP; MDC9; CORD9; Mltng; KIAA0021; MCMP; MDC9; MLTNG; ADAM 9

ADAM9_HUMAN

Goat

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

116496893

AAI26407.1

Q13443

90,556 Da

Degradation Of Collagen Pathway 730309!!Degradation Of The Extracellular Matrix Pathway 576263!!Extracellular Matrix Organization Pathway 576262

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

Function: Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP. Ref.3. Cofactor: Binds 1 zinc ion per subunit . Probable. Subunit structure: Interacts with SH3GL2 and SNX9 through its cytoplasmic tail. Ref.9. Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.3. Isoform 2: Secreted Ref.3. Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. Ref.1 Ref.3 Ref.4 Ref.8. Involvement in disease: Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11. Sequence similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain. Caution: Has sometimes been referred to as ADAM-12.

96 Strip Wells

600 USD