ELISA/assay

Sheep Adrenocorticotropic Hormone Receptor ELISA Kit

MBS007953

96 Strip Wells

600 USD

ELISA Kit

Sheep Adrenocorticotropic Hormone Receptor ELISA Kit

Adrenocorticotropic Hormone Receptor

adrenocorticotropic hormone receptor; Adrenocorticotropic hormone receptor; adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor; melanocortin 2 receptor (adrenocorticotropic hormone); Adrenocorticotropin receptor; Melanocortin receptor 2

ACTHR

MC2R; MC2R; ACTHR; ACTHR; ACTH receptor; ACTH-R; MC2-R

ACTHR_HUMAN

Sheep

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4505127

NP_000520.1

NM_000529.2

Q01718

33,927 Da

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Class A Rhodopsin-like Pathway 198886!!Neuroactive Ligand-receptor Interaction Pathway 83053!!Neuroactive Ligand-receptor Interaction Pathway 462!!Peptide GPCRs Pathway 198897!!Peptide Ligand-binding Receptors Pathway 106358!!Signal Transduction Pathway 477114

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]

Function: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Subunit structure: Interacts with FALP/MRAP. Ref.8. Subcellular location: Cell membrane; Multi-pass membrane protein. Tissue specificity: Melanocytes and corticoadrenal tissue. Involvement in disease: Glucocorticoid deficiency 1 (GCCD1) [MIM:202200]: A rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14. Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

96 Strip Wells

600 USD