Mouse Aggrecan ELISA Kit | MyBioSource MBS007919 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Aggrecan ELISA Kit

catalog :

MBS007919

quantity :

96 Strip Wells

price :

600 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS007919

products type :

ELISA Kit

products full name :

Mouse Aggrecan ELISA Kit

products short name :

Aggrecan

other names :

Aggrecan; Aggrecan core protein; aggrecan core protein; large aggregating proteoglycan; cartilage-specific proteoglycan core protein; chondroitin sulfate proteoglycan core protein 1; aggrecan; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1

products gene name :

AGC

other gene names :

ACAN; ACAN; AGC1; SEDK; AGCAN; CSPG1; MSK16; CSPGCP; AGC1; CSPG1; MSK16; CSPCP

uniprot entry name :

PGCA_HUMAN

reactivity :

Mouse

storage stability :

Store all reagents at 2-8 degree C

other info1 :

ELISA Type: Sandwich

ncbi gi num :

22209083

ncbi acc num :

AAH36445.1

uniprot acc num :

P16112

ncbi mol weight :

250,193 Da

ncbi pathways :

Disease Pathway 530764!!ECM Proteoglycans Pathway 833812!!Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Glycosaminoglycan Metabolism Pathway 645297!!Keratan Sulfate Biosynthesis Pathway 645302!!Keratan Sulfate Degradation Pathway 645303!!Keratan Sulfate/keratin Metabolism Pathway 645301!!MPS I - Hurler Syndrome Pathway 685537!!MPS II - Hunter Syndrome Pathway 685538

ncbi summary :

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Subunit structure: Interacts with FBLN1 . By similarity. Interacts with COMP. Ref.11. Subcellular location: Secreted extracellular space extracellular matrix . By similarity. Tissue specificity: Restricted to cartilages. Ref.4. Developmental stage: Expression was detected in chondrocytes throughout the developing skeleton. Domain: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3. Post-translational modification: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. Involvement in disease: Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts.Note: The disease is caused by mutations affecting the gene represented in this entry.Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13. Sequence similarities: Belongs to the aggrecan/versican proteoglycan family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 4 Link domains.Contains 1 Sushi (CCP/SCR) domain.

size :

96 Strip Wells

price :

600 USD

more info or order :

MyBioSource product webpage