ELISA/assay

Fish Serotonin Transporter ELISA Kit

MBS007797

48-Strip-Wells

435 USD

ELISA Kit

Fish Serotonin Transporter ELISA Kit

Serotonin Transporter

serotonin transporter, serotonin uptake site, 5-HT uptake site; Sodium-dependent serotonin transporter; sodium-dependent serotonin transporter; 5HT transporter; serotonin transporter 1; 5-hydroxytryptamine transporter; Na+/Cl- dependent serotonin transporter; 5-hydroxytryptamine (serotonin) transporter; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6 (neurotransmitter transporter), member 4; 5HT transporter; 5HTT; Solute carrier family 6 member 4

SERT

SLC6A4; SLC6A4; HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR; HTT; SERT; 5HTT

SC6A4_HUMAN

Fish

630

No significant cross-reactivity or interference between Fish SERT and analogues was observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Assay Type: Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

Intended Uses: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate SERT concentrations in Fish serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications. Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate SERT concentrations in Fish serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic or diagnostic applications!

300444

AAB26687.1

P31645

70,325 Da

Monoamine Transport Pathway (198851); SIDS Susceptibility Pathways (198901); Serotonergic Synapse Pathway (525336); Serotonin Transporter Activity Pathway (920962); Synaptic Vesicle Pathway (672457)

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

SERT: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; endomembrane system; endosome membrane; cytosol; lipid raft. Molecular Function: actin filament binding; serotonin transmembrane transporter activity; protein binding; protein homodimerization activity; serotonin:sodium symporter activity; myosin binding; cocaine binding; syntaxin-1 binding; monoamine transmembrane transporter activity; nitric-oxide synthase binding; Rab GTPase binding. Biological Process: response to drug; circadian rhythm; vasoconstriction; response to toxin; monoamine transport; positive regulation of cell cycle; social behavior; thalamus development; serotonin uptake; negative regulation of organ growth; negative regulation of synaptic transmission, dopaminergic; response to estradiol stimulus; memory; protein oligomerization; negative regulation of granule cell precursor proliferation; negative regulation of neuron differentiation; brain morphogenesis; response to hypoxia; sperm ejaculation; serotonin transport; transmembrane transport; protein homooligomerization; response to nutrient. Disease: Anxiety; Obsessive-compulsive Disorder

48-Strip-Wells

435 USD

96-Strip-Wells

600