catalog number :
MBS007586
products type :
ELISA Kit
products full name :
Goat A Disintegrin and Metalloprotease 19 ELISA Kit
products short name :
A Disintegrin and Metalloprotease 19
other names :
ADAM19 protein, partial; Disintegrin and metalloproteinase domain-containing protein 19; disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; meltrin-beta; metalloprotease-disintegrin meltrin beta; metalloprotease and disintegrin dendritic antigen marker; a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM metallopeptidase domain 19; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker
products gene name :
ADAM19
other gene names :
ADAM19; ADAM19; MLTNB; FKSG34; MADDAM; MLTNB; ADAM 19; MADDAM
uniprot entry name :
ADA19_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich
ncbi acc num :
AAH24214.2
ncbi mol weight :
104,997 Da
ncbi summary :
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
uniprot summary :
ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Protease; EC 3.4.24.-. Chromosomal Location of Human Ortholog: 5q33.3. Cellular Component: integral to membrane. Molecular Function: zinc ion binding; metalloendopeptidase activity; SH3 domain binding. Biological Process: heart development; membrane protein ectodomain proteolysis