ELISA/assay

Human Leucyl-Cystinyl Aminopeptidase ELISA Kit

MBS007258

96 Strip Wells

600 USD

ELISA Kit

Human Leucyl-Cystinyl Aminopeptidase ELISA Kit

Leucyl-Cystinyl Aminopeptidase

leucyl-cystinyl aminopeptidase isoform 1; Leucyl-cystinyl aminopeptidase; leucyl-cystinyl aminopeptidase; otase; oxytocinase; vasopressinase; AT (4) receptor; angiotensin IV receptor; insulin-regulated aminopeptidase; placental leucine aminopeptidase; insulin-responsive aminopeptidase; insulin-regulated membrane aminopeptidase; leucyl/cystinyl aminopeptidase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; Oxytocinase; OTase; Placental leucine aminopeptidase

LNPEP

LNPEP; LNPEP; CAP; IRAP; PLAP; P-LAP; OTASE; Cystinyl aminopeptidase; IRAP; OTase; P-LAP

LCAP_HUMAN

Human

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

61742777

NP_005566.2

NM_005575.2

Q9UIQ6

117,349 Da

Adaptive Immune System Pathway 366160!!Antigen Processing-Cross Presentation Pathway 477122!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Endosomal/Vacuolar Pathway 477125!!Immune System Pathway 106386!!Insulin-mediated Glucose Transport Pathway 137981!!Membrane Trafficking Pathway 106160!!Renin-angiotensin System Pathway 83075!!Renin-angiotensin System Pathway 486

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function: Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain. Ref.4 Ref.7 Ref.8. Catalytic activity: Release of an N-terminal amino acid, Cys- -Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however. Ref.4 Ref.7. Cofactor: Binds 1 zinc ion per subunit . By similarity. Subunit structure: Homodimer. Binds tankyrases 1 and 2. Subcellular location: Cell membrane; Single-pass type II membrane protein. Note: In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases. Ref.4Leucyl-cystinyl aminopeptidase, pregnancy serum form: Secreted. Note: During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition. Ref.4. Tissue specificity: Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon. Ref.1 Ref.2 Ref.4. Post-translational modification: The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.N-glycosylated. Sequence similarities: Belongs to the peptidase M1 family. Sequence caution: The sequence BAA09436.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD92120.1 differs from that shown. Reason: Frameshift at position 405.

96 Strip Wells

600 USD