ELISA/assay

Hamster Tissue Factor Pathway Inhibitor ELISA Kit

MBS007247

48-Strip-Wells

435 USD

ELISA Kit

Hamster Tissue Factor Pathway Inhibitor ELISA Kit

Tissue Factor Pathway Inhibitor

tissue factor pathway inhibitor isoform b; Tissue factor pathway inhibitor; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor

TFPI

TFPI; TFPI; EPI; TFI; LACI; TFPI1; LACI; TFPI1; TFPI; EPI; LACI

TFPI1_HUMAN

Hamster

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 31.2 ng/ml - 1000 ng/ml. Sensitivity: 5.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TFPI (hereafter termed this analyte) in undiluted original Hamster serum, plasma and tissue homogenate samples.

73760409

NP_001027452.1

NM_001032281.2

P10646

35,015 Da

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Extrinsic Pathway (106058); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Integrated Breast Cancer Pathway (219801); Syndecan-4-mediated Signaling Events Pathway (138064)

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]

TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Membrane protein, GPI anchor; Secreted, signal peptide; Inhibitor. Chromosomal Location of Human Ortholog: 2q32. Cellular Component: extracellular space; cell surface; endoplasmic reticulum; extracellular region; plasma membrane. Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity. Biological Process: blood coagulation, extrinsic pathway; blood coagulation

48-Strip-Wells

435 USD

96-Strip-Wells

600