ELISA/assay

Mouse Transforming Growth Factor Alpha ELISA Kit

MBS006972

96 Strip Wells

600 USD

ELISA Kit

Mouse Transforming Growth Factor Alpha ELISA Kit

Transforming Growth Factor Alpha

transforming growth factor-alpha; Protransforming growth factor alpha; protransforming growth factor alpha; TGF-alpha; transforming growth factor, alpha; EGF-like TGF; ETGF; TGF type 1

TGFA

TGFA; TGFA; TFGA; TGF-alpha; ETGF

TGFA_HUMAN

Mouse

Store all reagents at 2-8 degree C

Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids. Intended Uses: This ELISA kit is intended for laboratory in vitro research use only, not for drug, household or other use! The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm by a spectrophotometer. In order to measure the concentration of Mouse TGFA in the sample, this ELISA kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versus Mouse TGFA concentration. The concentration of Mouse TGFA in the samples is then determined by comparing the O.D. of the samples to the standard curve.

Detection Range: The detection range of this kit is 3.12 pg/ml ~ 100 pg/ml. Sensitivity: The sensitivity of this kit is less than 1.0 pg/ml. Intra-assay Precision: Intra-assay CV (%) are less than 15%. Inter-assay Precision: Inter-assay CV (%) are less than 15%.

6469923

AAF13491.1

P01135

17,006 Da

Direct P53 Effectors Pathway 137939!!ErbB Receptor Signaling Network Pathway 138016!!ErbB Signaling Pathway 198844!!ErbB Signaling Pathway 83049!!ErbB Signaling Pathway 458!!FOXM1 Transcription Factor Network Pathway 137935!!Glioma Pathway 83110!!Glioma Pathway 522!!Non-small Cell Lung Cancer Pathway 83119!!Non-small Cell Lung Cancer Pathway 531

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Subunit structure: Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Ref.16 Ref.17 Ref.18. Subcellular location: Transforming growth factor alpha: Secreted extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein. Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. Ref.6. Sequence similarities: Contains 1 EGF-like domain.

96 Strip Wells

600 USD