product summary
Loading...
company name :
MyBioSource
product type :
ELISA/assay
product name :
Goat Axis Inhibition Protein 2 ELISA Kit
catalog :
MBS006808
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS006808
products type :
ELISA Kit
products full name :
Goat Axis Inhibition Protein 2 ELISA Kit
products short name :
Axis Inhibition Protein 2
other names :
axin-2; Axin-2; axin-2; conductin; axin-like protein; axis inhibition protein 2; axin 2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin
products gene name :
AXIN2
other gene names :
AXIN2; AXIN2; AXIL; ODCRCS; Axil
uniprot entry name :
AXIN2_HUMAN
reactivity :
Goat
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich
ncbi gi num :
195927059
ncbi acc num :
NP_004646.3
ncbi gb acc num :
NM_004655.3
uniprot acc num :
Q9Y2T1
ncbi mol weight :
93,558 Da
ncbi pathways :
Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Canonical Wnt Signaling Pathway (138032); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); Endometrial Cancer Pathway (83109); Endometrial Cancer Pathway (521); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Neural Crest Differentiation Pathway (672460)
ncbi summary :
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
uniprot summary :
axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 17q24.1. Cellular Component: Golgi apparatus; centrosome; postsynaptic density; cytoplasmic membrane-bound vesicle; cell cortex; cytosol; beta-catenin destruction complex; nucleoplasm; microtubule cytoskeleton; cytoplasmic microtubule; cytoplasm; plasma membrane; nucleus. Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity. Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; negative regulation of osteoblast differentiation; dorsal/ventral axis specification; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity. Disease: Oligodontia-colorectal Cancer Syndrome
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!