ELISA/assay

Porcine Islet Amyloid Polypeptide ELISA Kit

MBS005916

96 Strip Wells

600 USD

ELISA Kit

Porcine Islet Amyloid Polypeptide ELISA Kit

Islet Amyloid Polypeptide

islet amyloid polypeptide; Islet amyloid polypeptide; islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin); islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide

IAPP

IAPP; IAPP; DAP; IAP; DAP

IAPP_HUMAN

Porcine

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4557655

NP_000406.1

NM_000415.2

P10997

9,806 Da

Amyloids Pathway 366238!!Calcitonin-like Ligand Receptors Pathway 106379!!Class B/2 (Secretin Family Receptors) Pathway 106378!!Developmental Biology Pathway 477129!!Disease Pathway 530764!!G Alpha (s) Signalling Events Pathway 119549!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Integrated Pancreatic Cancer Pathway 711360!!Maturity Onset Diabetes Of The Young Pathway 83096

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Subunit structure: Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation. Ref.18. Subcellular location: Secreted Ref.7. Domain: The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. Ref.7 Ref.19 Ref.20. Post-translational modification: Amyloid fibrils are degraded by IDE. Miscellaneous: IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Sequence similarities: Belongs to the calcitonin family. Mass spectrometry: Molecular mass is 3936 Da from positions 34 - 70. Determined by MALDI. Ref.7

96 Strip Wells

600 USD