ELISA/assay

Fish Axis Inhibition Protein 2 ELISA Kit

MBS005891

96 Strip Wells

600 USD

ELISA Kit

Fish Axis Inhibition Protein 2 ELISA Kit

Axis Inhibition Protein 2

axin-2; Axin-2; axin-2; conductin; axin-like protein; axis inhibition protein 2; axin 2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin

AXIN2

AXIN2; AXIN2; AXIL; ODCRCS; Axil

AXIN2_HUMAN

Fish

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

195927059

NP_004646.3

NM_004655.3

Q9Y2T1

93,558 Da

Basal Cell Carcinoma Pathway 83113!!Basal Cell Carcinoma Pathway 525!!Canonical Wnt Signaling Pathway 138032!!Colorectal Cancer Pathway 83106!!Colorectal Cancer Pathway 518!!Endometrial Cancer Pathway 83109!!Endometrial Cancer Pathway 521!!Hippo Signaling Pathway 749777!!Hippo Signaling Pathway 750388!!Neural Crest Differentiation Pathway 672460

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B . By similarity. Subunit structure: Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin . By similarity. Interacts with SMAD7 and RNF111. Interacts with ANKRD6. Ref.8 Ref.9 Ref.11. Subcellular location: Cytoplasm. Tissue specificity: Expressed in brain and lymphoblast. Domain: The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2 . By similarity. Post-translational modification: Probably phosphorylated by GSK3B and dephosphorylated by PP2A . By similarity.ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. Ref.9 Ref.10 Ref.11. Involvement in disease: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.Note: The gene represented in this entry is involved in disease pathogenesis.Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7. Sequence similarities: Contains 1 DIX domain.Contains 1 RGS domain.

96 Strip Wells

600 USD