catalog number :
MBS005850
products type :
ELISA Kit
products full name :
Fish Heme Oxygenase 2, Decycling ELISA Kit
products short name :
Heme Oxygenase 2, Decycling
other names :
heme oxygenase 2; Heme oxygenase 2; heme oxygenase 2; heme oxygenase (decycling) 2
other gene names :
HMOX2; HMOX2; HO-2; HO2; HO-2
uniprot entry name :
HMOX2_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
ELISA Type: Sandwich
ncbi acc num :
NP_002125.3
ncbi gb acc num :
NM_002134.3
ncbi mol weight :
36,033 Da
ncbi pathways :
Heme Degradation Pathway 160971!!Iron Uptake And Transport Pathway 187191!!Metabolism Pathway 477135!!Metabolism Of Porphyrins Pathway 106325!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Porphyrin And Chlorophyll Metabolism Pathway 83021!!Porphyrin And Chlorophyll Metabolism Pathway 407!!Transmembrane Transport Of Small Molecules Pathway 106572!!Heme Degradation Pathway 545346
ncbi summary :
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Catalytic activity: Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O. Subcellular location: Microsome. Endoplasmic reticulum. Induction: Heme oxygenase 2 activity is non-inducible. Sequence similarities: Belongs to the heme oxygenase family.Contains 2 HRM (heme regulatory motif) repeats.