ELISA/assay

Mouse Atrial Natriuretic Peptide ELISA Kit

MBS005692

96 Strip Wells

600 USD

ELISA Kit

Mouse Atrial Natriuretic Peptide ELISA Kit

Atrial Natriuretic Peptide

atrial natriuretic peptide; Natriuretic peptides A; natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A; natriuretic peptide A; CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDPAtrial natriuretic factor; ANF; Alternative name(s):; Atrial natriuretic peptide

ANP

NPPA; NPPA; ANF; ANP; PND; ATFB6; CDD-ANF; ANP; PND; CDP; ANF; ANP

ANF_HUMAN

Mouse

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

178638

AAA35529.1

P01160

16,708 Da

Amyloids Pathway 366238!!Disease Pathway 530764!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!HIF-1 Signaling Pathway 695200!!MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway 576276

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Ref.15. Subcellular location: Secreted. Post-translational modification: Cleaved by CORIN upon secretion to produce the functional hormone. Polymorphism: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide. Involvement in disease: Familial atrial fibrillation 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20. Sequence similarities: Belongs to the natriuretic peptide family. Sequence caution: The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation.

96 Strip Wells

600 USD