ELISA/assay

Goat Mucosal Vascular Addressin Cell Adhesion Molecule 1 ELISA Kit

MBS005653

96 Strip Wells

600 USD

ELISA Kit

Goat Mucosal Vascular Addressin Cell Adhesion Molecule 1 ELISA Kit

Mucosal Vascular Addressin Cell Adhesion Molecule 1

mucosal addressin cell adhesion molecule 1 isoform a; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1

MADCAM-1

MADCAM1; MADCAM1; MACAM1; MAdCAM-1; hMAdCAM-1

MADCA_HUMAN

Goat

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

109633022

NP_570116.2

NM_130760.2

Q13477

40,155 Da

Adaptive Immune System Pathway 366160!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Immune System Pathway 106386!!Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway 106413!!Integrin Cell Surface Interactions Pathway 106110!!Intestinal Immune Network For IgA Production Pathway 128760!!Intestinal Immune Network For IgA Production Pathway 128670!!Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway 137971!!Signal Transduction Pathway 477114

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. Subunit structure: Homodimer . Probable. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. Ref.1 Ref.2. Post-translational modification: The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation . By similarity. Polymorphism: The number of repeats in the mucin domain varies between 5 and 8 repeats. Sequence similarities: Contains 2 Ig-like (immunoglobulin-like) domains.

96 Strip Wells

600 USD