catalog number :
MBS005385
products type :
ELISA Kit
products full name :
Fish Aquaporin 2, Collecting Duct ELISA Kit
products short name :
Aquaporin 2, Collecting Duct
other names :
aquaporin-2; Aquaporin-2; aquaporin-2; AQP-2; aquaporin-CD; ADH water channel; water-channel aquaporin 2; collecting duct water channel protein; water channel protein for renal collecting duct; aquaporin 2 (collecting duct); ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
products gene name :
AQP-2
other gene names :
AQP2; AQP2; AQP-CD; WCH-CD; AQP-2; AQP-CD
uniprot entry name :
AQP2_HUMAN
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich
ncbi acc num :
NP_000477.1
ncbi gb acc num :
NM_000486.5
ncbi mol weight :
28,837 Da
ncbi pathways :
Aquaporin-mediated Transport Pathway (187187); Passive Transport By Aquaporins Pathway (187188); Regulation Of Water Balance By Renal Aquaporins Pathway (187189); Transmembrane Transport Of Small Molecules Pathway (106572); Vasopressin-regulated Water Reabsorption Pathway (143700); Vasopressin-regulated Water Reabsorption Pathway (143631)
ncbi summary :
This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
uniprot summary :
AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family. Protein type: Membrane protein, integral; Channel, misc.; Transporter, aquaporin family; Membrane protein, multi-pass; Transporter. Chromosomal Location of Human Ortholog: 12q12-q13. Cellular Component: recycling endosome; protein complex; clathrin-coated vesicle; membrane; rough endoplasmic reticulum; basolateral plasma membrane; lysosome; integral to plasma membrane; early endosome; apical plasma membrane; plasma membrane; trans-Golgi network. Molecular Function: water transporter activity; glycerol transmembrane transporter activity; actin binding; water channel activity; glycerol channel activity; PDZ domain binding. Biological Process: actin filament depolymerization; glycerol transport; response to glucagon stimulus; cellular water homeostasis; apoptosis; response to lithium ion; water transport; response to lipopolysaccharide; cellular response to water deprivation; female pregnancy; excretion; response to salt stress; response to starvation; hyperosmotic response; renal water transport; renal water homeostasis; response to calcium ion; positive regulation of calcium ion transport; transmembrane transport; aging. Disease: Diabetes Insipidus, Nephrogenic, Autosomal