ELISA/assay

Fish Azidothymidine ELISA Kit

MBS005264

48-Strip-Wells

435 USD

ELISA Kit

Fish Azidothymidine ELISA Kit

Azidothymidine

ATP-binding cassette sub-family G member 2; ATP-binding cassette sub-family G member 2; ATP-binding cassette sub-family G member 2; urate exporter; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter G2; mitoxantrone resistance-associated protein; placenta-specific ATP-binding cassette transporter; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; ATP-binding cassette, sub-family G (WHITE), member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter

AZT

ABCG2; ABCG2; MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1; EST157481; ABCP; BCRP; BCRP1; MXR

ABCG2_HUMAN

Fish

655

Store all reagents at 2-8 degree C

Assay Type: Sandwich

67462103

Q9UNQ0.3

Q9UNQ0

72,314 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Abacavir Transmembrane Transport Pathway (645350); Abacavir Transport And Metabolism Pathway (645349); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Fluoropyrimidine Activity Pathway (198778); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Irinotecan Pathway (198905)

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

ABCG2: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. Monomer or homodimer; disulfide-linked. Up-regulated in brain tumors. Highly expressed in placenta. Low expression in small intestine, liver and colon. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter; Transporter, iron; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family. Chromosomal Location of Human Ortholog: 4q22. Cellular Component: nucleoplasm; mitochondrial membrane; integral to membrane; plasma membrane; nucleus. Molecular Function: protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity; heme transporter activity; xenobiotic-transporting ATPase activity; ATP binding. Biological Process: response to drug; heme transport; urate metabolic process; transport; cellular iron ion homeostasis; xenobiotic transport; multidrug transport; transmembrane transport. Disease: Blood Group, Junior System; Uric Acid Concentration, Serum, Quantitative Trait Locus 1

48-Strip-Wells

435 USD

96-Strip-Wells

600