ELISA/assay

Goat Aquaporin 2, Collecting Duct ELISA Kit

MBS005145

96 Strip Wells

600 USD

ELISA Kit

Goat Aquaporin 2, Collecting Duct ELISA Kit

Aquaporin 2, Collecting Duct

aquaporin-2; Aquaporin-2; aquaporin-2; AQP-2; aquaporin-CD; ADH water channel; water-channel aquaporin 2; collecting duct water channel protein; water channel protein for renal collecting duct; aquaporin 2 (collecting duct); ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct

AQP-2

AQP2; AQP2; AQP-CD; WCH-CD; AQP-2; AQP-CD

AQP2_HUMAN

Goat

Store all reagents at 2-8 degree C

ELISA Type: Sandwich

4502179

NP_000477.1

NM_000486.5

P41181

28,837 Da

Aquaporin-mediated Transport Pathway 187187!!Passive Transport By Aquaporins Pathway 187188!!Regulation Of Water Balance By Renal Aquaporins Pathway 187189!!Transmembrane Transport Of Small Molecules Pathway 106572!!Vasopressin-regulated Water Reabsorption Pathway 143700!!Vasopressin-regulated Water Reabsorption Pathway 143631

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

Function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Subcellular location: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein . By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus trans-Golgi network membrane; Multi-pass membrane protein. Note: Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. Ref.7. Tissue specificity: Expressed in renal collecting tubules. Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Post-translational modification: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. Involvement in disease: Diabetes insipidus, nephrogenic, autosomal (ANDI) [MIM:125800]: A disorder caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. Characterized by excessive water drinking (polydipsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.3 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22. Sequence similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

96 Strip Wells

600 USD