Rabbit MAPKAPK2 (Phospho-Ser272) Antibody | MyBioSource MBS004662 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit MAPKAPK2 (Phospho-Ser272) Antibody

catalog :

MBS004662

quantity :

0.05 mL

price :

270 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS004662

products type :

Antibody

products full name :

Rabbit MAPKAPK2 (Phospho-Ser272) Antibody

products short name :

MAPKAPK2 (Phospho-Ser272)

other names :

MAP kinase-activated protein kinase 2 isoform 1; MAP kinase-activated protein kinase 2; MAP kinase-activated protein kinase 2; MAPKAP kinase 2; MAPK-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2

products gene name :

MAPKAPK2

other gene names :

MAPKAPK2; MAPKAPK2; MK2; MK-2; MAPKAP-K2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2

uniprot entry name :

MAPK2_HUMAN

isotype :

IgG

host :

Rabbit

reactivity :

Human (Identities = 100%, Positives = 100%); . Mouse (Identities = 100%, Positives = 100%); . Rat (Identities = 100%, Positives = 100%)

sequence length :

370

specificity :

MAPKAPK2 (Phospho-Ser272) antibody detects endogenous levels of MAPKAPK2 only when phosphorylated at serine 272.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1 mg/ml

storage stability :

Store at -20 Degree C/1 year

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

WB: 1:500~1:3000 . IHC: 1:50~1:100. ELISA: 1:1000

other info1 :

All Sites: Human: Ser272; Mouse: Ser258; Rat: Ser258

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of serine 272 (A-I-SP-P-G).

ncbi gi num :

10863901

ncbi acc num :

NP_004750.1

ncbi gb acc num :

NM_004759.4

uniprot acc num :

P49137

ncbi mol weight :

45,568 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Arachidonic Acid Metabolism Pathway (685553); B Cell Receptor Signaling Pathway (198909); CREB Phosphorylation Pathway (106484); Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway (187213); Destabilization Of MRNA By Tristetraprolin (TTP) Pathway (187214); FAS Pathway And Stress Induction Of HSP Regulation (198894); Gene Expression Pathway (105937); IL-3 Signaling Pathway (198881); IL-6 Signaling Pathway (198864)

ncbi summary :

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

MAPKAPK2: a member of the MAPKAPK family of protein kinases. It is phosphorylated and activated by p38 in response to cytokines, stress and chemotactic factors.MAPKAPK-2 is apparently a direct target of p38 MAPK. HSP27 is one of its in vivo substrates. Two transcript variants encoding two different isoforms have been described. Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; CAMK group; MAPKAPK family; MAPKAPK subfamily. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus; cytosol. Molecular Function: protein serine/threonine kinase activity; signal transducer activity; protein binding; ATP binding; protein kinase activity. Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; stress-activated MAPK cascade; response to lipopolysaccharide; leukotriene metabolic process; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of interleukin-6 production; arachidonic acid metabolic process; response to stress; inflammatory response; toll-like receptor 4 signaling pathway; inner ear development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cytokine stimulus; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; regulation of tumor necrosis factor production; gene expression; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; G2/M transition DNA damage checkpoint; response to DNA damage stimulus

size1 :

0.05 mL

price1 :

270 USD

size2 :

0.1 mL

price2 :

445

more info or order :

MyBioSource product webpage