antibody

Rabbit 14-3-3 eta Antibody

MBS004463

0.05 ml

270 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit 14-3-3 eta Antibody

14-3-3 eta

14-3-3 protein eta; 14-3-3 protein eta; 14-3-3 protein eta; 14-3-3 eta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Protein AS1

14-3-3 eta

YWHAH; YWHAH; YWHA1; YWHA1

1433F_HUMAN

Rabbit

Human, mouse, rat

246

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

4507951

NP_003396.1

NM_003405.3

Q04917

28,219 Da

Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 198811!!Cell Cycle Pathway 83054!!Cell Cycle Pathway 463!!Class I PI3K Signaling Events Mediated By Akt Pathway 138020!!Epstein-Barr Virus Infection Pathway 585562

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. Ref.13. Subunit structure: Homodimer . By similarity. Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 . By similarity. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 . By similarity. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.19. Tissue specificity: Expressed mainly in the brain and present in other tissues albeit at lower levels. Post-translational modification: Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion . By similarity. Sequence similarities: Belongs to the 14-3-3 family.

0.05 ml

270 USD