Rabbit p70 S6 Kinase (Phospho-Thr389/412) Antibody | MyBioSource MBS004222 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit p70 S6 Kinase (Phospho-Thr389/412) Antibody

catalog :

MBS004222

quantity :

0.05 mL

price :

270 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS004222

products type :

Antibody

products full name :

Rabbit p70 S6 Kinase (Phospho-Thr389/412) Antibody

products short name :

p70 S6 Kinase (Phospho-Thr389/412)

other names :

ribosomal protein S6 kinase beta-1 isoform e; Ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase beta-1; p70 S6 kinase, alpha; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; ribosomal protein S6 kinase, 70kDa, polypeptide 1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha

other gene names :

RPS6KB1; RPS6KB1; S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha; STK14A; S6K-beta-1; S6K1; P70S6K1; p70-S6K 1; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA

uniprot entry name :

KS6B1_HUMAN

isotype :

IgG

host :

Rabbit

reactivity :

Human, mouse, rat

sequence length :

502

specificity :

Phospho-p70 S6 Kinase (Thr389/412) Antibody detects endogenous levels of p70 S6 Kinase only when phosphorylated at Threonine 389/412

purity :

Immunogen affinity purified

form :

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

concentration :

1 mg/ml

tested application :

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

WB 1:500-1:2000 . IHC 1:50-1:200 . IF/ICC 1:100-1:500 . Optimal dilutions/concentrations should be determined by the end user.

products description :

Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein.

ncbi gi num :

440546416

ncbi acc num :

NP_001258989.1

ncbi gb acc num :

NM_001272060.1

uniprot acc num :

P23443

ncbi mol weight :

70kDa

ncbi pathways :

AMPK Signaling Pathway (198868); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); CDC42 Signaling Events Pathway (137994); Cytoplasmic Ribosomal Proteins Pathway (198853); ErbB Signaling Pathway (198844); ErbB Signaling Pathway (83049)

ncbi summary :

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

uniprot summary :

p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5 oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported. Protein type: Kinase, protein; Translation; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; RSK family; p70 subfamily. Chromosomal Location of Human Ortholog: 17q23.1

size1 :

0.05 mL

price1 :

270 USD

size2 :

0.1 mL

price2 :

445

more info or order :

MyBioSource product webpage