Rabbit SLC24A6 Antibody | MyBioSource MBS004052 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit SLC24A6 Antibody

catalog :

MBS004052

quantity :

0.1 mL

price :

440 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of extracts from MCF-7 cells using SLC24A6 antibody.

product information

catalog number :

MBS004052

products type :

Antibody

products full name :

Rabbit SLC24A6 Antibody

products short name :

[SLC24A6]

products name syn :

[FLJ22233; Na(+)/K(+)/Ca(2+) exchange protein 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; NCKX6; NCKX6_HUMAN; NCLX; Slc24a6; Sodium/potassium/calcium exchanger; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6; Solute carrier family 24 member 6]

other names :

[sodium/potassium/calcium exchanger 6, mitochondrial; Sodium/potassium/calcium exchanger 6, mitochondrial; sodium/potassium/calcium exchanger 6, mitochondrial; solute carrier family 24 member 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; sodium/calcium exchanger protein, mitochondrial; solute carrier family 24 (sodium/potassium/calcium exchanger), member 6; solute carrier family 24 (sodium/lithium/calcium exchanger), member 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Solute carrier family 24 member 6]

products gene name :

[SLC24A6]

other gene names :

[SLC24A6; SLC24A6; NCLX; NCKX6; NCKX6; NCLX]

uniprot entry name :

NCKX6_HUMAN

clonality :

polyclonal

host :

rabbit

reactivity :

Human

sequence length :

584

specificity :

SLC24A6 Antibody detects endogenous levels of total SLC24A6

purity :

Immunogen affinity purified

form :

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

storage stability :

Store at -20 °C.Stable for 12 months from date of receipt

app notes :

WB 1:500~1:1000. ELISA(peptide) 1:20000-1:40000. Optimal dilutions/concentrations should be determined by the end user.

image1 heading :

Western Blot (WB)

other info1 :

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Immunogen: A synthesized peptide. Function: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).

ncbi gi num :

39995086

ncbi acc num :

NP_079235.2

ncbi gb acc num :

NM_024959.2

uniprot acc num :

Q6J4K2

ncbi pathways :

SLC-mediated Transmembrane Transport Pathway (119558); Sodium/Calcium Exchangers Pathway (119561); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway (119559)

ncbi summary :

SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008]

uniprot summary :

SLC24A6: Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+). Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral; Calcium-binding. Chromosomal Location of Human Ortholog: 12q24.13. Cellular Component: mitochondrial crista; plasma membrane; sarcolemma. Molecular Function: protein homodimerization activity; calcium:sodium antiporter activity. Biological Process: mitochondrial calcium ion homeostasis; cytosolic calcium ion homeostasis; response to stimulus; ion transport; glucose homeostasis; regulation of insulin secretion; transmembrane transport; mitochondrial calcium ion transport

size1 :

0.1 mL

price1 :

440 USD

size2 :

0.2 mL

price2 :

715

more info or order :

MyBioSource product webpage