Rabbit GHRHR Antibody | MyBioSource MBS003751 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit GHRHR Antibody

catalog :

MBS003751

quantity :

0.05 mL

price :

270 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS003751

products type :

Antibody

products full name :

Rabbit GHRHR Antibody

products short name :

GHRHR

other names :

growth hormone-releasing hormone receptor; Growth hormone-releasing hormone receptor; growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor; growth hormone releasing hormone receptor; Growth hormone-releasing factor receptor

products gene name :

GHRHR

other gene names :

GHRHR; GHRHR; GRFR; GHRFR; IGHD1B; GHRH receptor; GRF receptor; GRFR

uniprot entry name :

GHRHR_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

423

specificity :

GHRHR antibody detects endogenous levels of total GHRHR protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg^2+ and Ca^2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C

tested application :

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

app notes :

WB: 1:500~1:3000 . IF: 1:100~1:500. ELISA: 1:1000

other info1 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human GHRHR.

ncbi gi num :

58530851

ncbi acc num :

NP_000814.2

ncbi gb acc num :

NM_000823.3

uniprot acc num :

Q02643

ncbi mol weight :

47,402 Da

ncbi pathways :

Class B/2 (Secretin Family Receptors) Pathway (106378); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class B Secretin-like Pathway (198781); GPCRs, Other Pathway (198765); Glucagon-type Ligand Receptors Pathway (106380); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Signal Transduction Pathway (477114)

ncbi summary :

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

uniprot summary :

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family. Protein type: GPCR, family 2; Membrane protein, integral; Cell development/differentiation; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 7p14. Cellular Component: nuclear outer membrane; cell surface; nuclear matrix; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule. Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity. Biological Process: lactation; positive regulation of insulin-like growth factor receptor signaling pathway; response to glucocorticoid stimulus; regulation of protein metabolic process; cell maturation; adenylate cyclase activation; positive regulation of multicellular organism growth; determination of adult life span; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; somatotropin secreting cell development; hormone metabolic process; regulation of steroid hormone receptor signaling pathway. Disease: Isolated Growth Hormone Deficiency, Type Ib

size1 :

0.05 mL

price1 :

270 USD

size2 :

0.1 mL

price2 :

445

more info or order :

MyBioSource product webpage