antibody

Rabbit NRF1 Antibody

MBS003165

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit NRF1 Antibody

NRF1

Nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal; NRF1

nuclear respiratory factor 1; Nuclear respiratory factor 1; nuclear respiratory factor 1; NRF-1; alpha palindromic-binding protein; nuclear respiratory factor 1; Alpha palindromic-binding protein

NRF1

NRF1; NRF1; ALPHA-PAL; NRF-1; Alpha-pal

NRF1_HUMAN

IgG

Rabbit

Human (Identities = 100%, Positives = 100%); . Mouse (Identities = 100%, Positives = 100%); . Rat (Identities = 100%, Positives = 100%)

503

NRF1 antibody detects endogenous levels of total NRF1 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Store at -20 Degree C/1 year

ELISA (EIA), Western Blot (WB)

WB: 1:500~1:3000 . ELISA: 1:1000

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human NRF1.

93141039

NP_001035199.1

NM_001040110.1

Q16656

53,541 Da

Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Mitochondrial Gene Expression Pathway (198757); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]

NRF1: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Belongs to the NRF1/Ewg family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: nucleoplasm; cytoplasm. Biological Process: regulation of transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; organ regeneration; generation of precursor metabolites and energy; transcription, DNA-dependent; response to folic acid; organelle organization and biogenesis; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; cellular lipid metabolic process; response to electrical stimulus; response to estradiol stimulus

0.05 mL

270 USD

0.1 mL

445