product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit PLD2 (Phospho-Tyr169) Antibody
catalog :
MBS002756
quantity :
0.1 mL
price :
440 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS002756
products type :
Antibody
products full name :
Rabbit PLD2 (Phospho-Tyr169) Antibody
products short name :
[PLD2 (Phospho-Tyr169)]
other names :
[phospholipase D2 isoform PLD2B; Phospholipase D2; phospholipase D2; PLD1C; hPLD2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D2; Choline phosphatase 2; PLD1C; Phosphatidylcholine-hydrolyzing phospholipase D2]
products gene name :
[PLD2]
other gene names :
[PLD2; PLD2; PLD 2; hPLD2]
uniprot entry name :
PLD2_HUMAN
clonality :
polyclonal
host :
rabbit
reactivity :
Human (Identities = 100%, Positives = 100%). Mouse (Identities = 100%, Positives = 100%). Rat (Identities = 100%, Positives = 100%)
sequence length :
922
specificity :
PLD2 (Phospho-Tyr169) antibody detects endogenous levels of PLD2 only when phosphorylated at tyrosine 169.
form :
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
concentration :
1 mg/ml
storage stability :
Store at -20 degree C
tested application :
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
WB: 1:500~1:3000 . IHC: 1:50~1:100 . ELISA: 1:10000
image1 heading :
Immunohistochemistry
image2 heading :
Western Blot
other info1 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PLD2 around the phosphorylation site of tyrosine 169 (E-N-YP-L-N).
other info2 :
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
ncbi gi num :
340805823
ncbi acc num :
NP_001230037.1
ncbi gb acc num :
NM_001243108.1
uniprot acc num :
O14939
ncbi pathways :
Alpha-synuclein Signaling Pathway (137913); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf1 Pathway (137927); Arf6 Downstream Pathway (138038); Arf6 Trafficking Events Pathway (137954); EGFR1 Signaling Pathway (198782); Endocytosis Pathway (102279); Endocytosis Pathway (102181); ErbB1 Downstream Signaling Pathway (138057); Ether Lipid Metabolism Pathway (82990)
ncbi summary :
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
uniprot summary :
PLD2: a phosphatidylcholine-specific phospholipase D. Catalyzes the hydrolysis of PC to produce phosphatidic acid and choline. Activated as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. May function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. Enriched in caveolae; may be involved in MEK/ERK signaling cascades induced by the VEGF/VEGFR-2/PKC-delta pathway in endothelial cells. Three alternatively spliced isoforms have been described. Protein type: Motility/polarity/chemotaxis; EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Phospholipase. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: endoplasmic reticulum membrane; brush border membrane; plasma membrane. Molecular Function: protein binding; phospholipase D activity; phosphoinositide binding. Biological Process: G-protein coupled receptor internalization; phosphatidylglycerol biosynthetic process; small GTPase mediated signal transduction; phospholipid metabolic process; glycerophospholipid biosynthetic process; innate immune response; phosphatidic acid biosynthetic process; cytoskeleton organization and biogenesis; lipid catabolic process
size1 :
0.1 mL
price1 :
440 USD
size2 :
0.2 mL
price2 :
715
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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