antibody

Rabbit CRMP-2 (Phospho-Ser522) Antibody

MBS002599

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit CRMP-2 (Phospho-Ser522) Antibody

CRMP-2 (Phospho-Ser522)

dihydropyrimidinase-related protein 2 isoform 1; Dihydropyrimidinase-related protein 2; dihydropyrimidinase-related protein 2; unc-33-like phosphoprotein 2; collapsin response mediator protein hCRMP-2; dihydropyrimidinase-like 2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2

CRMP-2

DPYSL2; DPYSL2; DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2; CRMP2; ULIP2; DRP-2; CRMP-2; ULIP-2

DPYL2_HUMAN

Rabbit

Human; Mouse; Rat

677

CRMP-2 (Phospho-Ser522) antibody detects endogenous levels of DPYSL2 only when phosphorylated at serine 522.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Store at -20 degree C/1 year

ELISA (EIA), Western Blot (WB)

WB: 1:500~1:3000 . ELISA: 1:10000

All Sites: Human: Ser522; Mouse: Ser522; Rat: Ser522. Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human DPYSL2 around the phosphorylation site of serine 522.

308818195

NP_001184222.1

NM_001197293.2

Q16555

62,294 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); BDNF Signaling Pathway (712093); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003); Recycling Pathway Of L1 (161004); Regulation Of Microtubule Cytoskeleton Pathway (755439); Semaphorin Interactions Pathway (119519)

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). Protein type: Motility/polarity/chemotaxis; Microtubule-binding. Chromosomal Location of Human Ortholog: 8p22-p21. Cellular Component: microtubule; growth cone; cell soma; mitochondrion; membrane; dendrite; terminal button; cytosol. Molecular Function: dihydropyrimidinase activity; protein binding; protein kinase binding. Biological Process: response to drug; nervous system development; axon guidance; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; endocytosis; cytoskeleton organization and biogenesis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

0.05 mL

270 USD

0.1 mL

445