Rabbit ADRB1 Antibody | MyBioSource MBS002474 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit ADRB1 Antibody

catalog :

MBS002474

quantity :

0.1 mL

price :

440 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS002474

products type :

Antibody

products full name :

Rabbit ADRB1 Antibody

products short name :

[ADRB1]

other names :

[beta-1 adrenergic receptor; Beta-1 adrenergic receptor; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; adrenergic, beta-1-, receptor; adrenoceptor beta 1; Beta-1 adrenoreceptor]

products gene name :

[ADRB1]

other gene names :

[ADRB1; ADRB1; RHR; B1AR; ADRB1R; BETA1AR; ADRB1R; B1AR; Beta-1 adrenoceptor]

uniprot entry name :

ADRB1_HUMAN

clonality :

polyclonal

host :

rabbit

reactivity :

Human, Mouse, Rat

sequence length :

477

specificity :

ADRB1 antibody detects endogenous levels of total ADRB1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg^2+ and Ca^2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

WB: 1:500~1:3000 . ELISA: 1:20000

image1 heading :

Western Blot

ncbi gi num :

4557265

ncbi acc num :

NP_000675.1

ncbi gb acc num :

NM_000684.2

uniprot acc num :

P08588

ncbi pathways :

Adrenoceptors Pathway (106365); Amine Ligand-binding Receptors Pathway (106363); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Endocytosis Pathway (102279); Endocytosis Pathway (102181)

ncbi summary :

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

uniprot summary :

ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 10q25.3. Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus. Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; drug binding; norepinephrine binding; epinephrine binding; beta-adrenergic receptor activity; alpha-2A adrenergic receptor binding; Ras guanyl-nucleotide exchange factor activity; beta1-adrenergic receptor activity; PDZ domain binding. Biological Process: fear response; diet induced thermogenesis; wound healing; positive regulation of apoptosis; apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; sensory perception of pain; positive regulation of saliva secretion; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; aging; glycogen catabolic process; negative regulation of multicellular organism growth; adenylate cyclase activation; regulation of calcium ion transport; memory; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure. Disease: Resting Heart Rate, Variation In

size1 :

0.1 mL

price1 :

440 USD

size2 :

0.2 mL

price2 :

715

more info or order :

MyBioSource product webpage