antibody

Rabbit YAP (Phospho-Ser127) Antibody

MBS002434

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit YAP (Phospho-Ser127) Antibody

YAP (Phospho-Ser127)

yorkie homolog isoform 1; Yorkie homolog; yorkie homolog; yes-associated protein 2; yes-associated protein beta; yes-associated protein delta; 65 kDa Yes-associated protein; Yes-associated protein 1; 65 kDa Yes-associated protein

YAP

YAP1; YAP1; YAP; YKI; YAP2; YAP65; YAP65; YAP65

YAP1_HUMAN

IgG

Rabbit

Human, Mouse, Rat

504

YAP (Phospho-Ser127) antibody detects endogenous levels of YAP only when phosphorylated at serine 127.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Store at -20 degree C up to 1 year.

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

WB: 1:500~1:2000. IHC: 1:50~1:200 . Optimal dilutions/concentrations should be determined by the end user.

194306653

NP_001123617.1

NM_001130145.2

P46937

54,462 Da

ErbB4 Signaling Events Pathway (137991); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Nuclear Signaling By ERBB4 Pathway (530744); PPARA Activates Gene Expression Pathway (530749)

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction. [provided by RefSeq, Jul 2008]

YAP1: an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules. Protein type: Oncoprotein; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: nucleoplasm; transcription factor complex; membrane; cytoplasm; cell junction; cytosol; nucleus. Molecular Function: protein binding; transcription coactivator activity; chromatin binding; transcription corepressor activity. Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; somatic stem cell maintenance; lateral mesoderm development; cell morphogenesis; negative regulation of epithelial cell differentiation; notochord development; positive regulation of organ growth; keratinocyte differentiation; cell proliferation; positive regulation of cell proliferation; gene expression; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; response to DNA damage stimulus. Disease: Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/palate, And/or Mental Retardation

0.05 mL

270 USD

0.1 mL

445