catalog number :
MBS001970
products full name :
Rabbit AZI2 Antibody
products short name :
AZI2
other names :
5-azacytidine-induced protein 2 isoform a; 5-azacytidine-induced protein 2; 5-azacytidine-induced protein 2; NAK-associated protein 1; 5-azacytidine induced gene 2; NF-kappa-B-activating kinase-associated protein 1; 5-azacytidine induced 2; NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP
products gene name :
AZI2
other gene names :
AZI2; AZI2; AZ2; NAP1; TILP; NAP1; Nak-associated protein 1
uniprot entry name :
AZI2_HUMAN
reactivity :
Human, mouse, rat
specificity :
AZI2 antibody detects endogenous levels of total AZI2 protein.
purity :
The antibody was affinity-purifed from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
storage stability :
Store at -20 deg. C/ 1 year
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:500~1:3000; ELISA: 1:20000
other info1 :
Immunogen:: The antiserum was prduced against synthesized peptide dervied from N-terminal of human AZI2.
ncbi acc num :
NP_071906.1
ncbi gb acc num :
NM_022461.4
ncbi mol weight :
44,935 Da
ncbi pathways :
RIG-I-like Receptor Signaling Pathway (117292); RIG-I-like Receptor Signaling Pathway (116128); TNF-alpha/NF-kB Signaling Pathway (198884)
ncbi summary :
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
uniprot summary :
AZI2: Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 3p24.1. Cellular Component: cytoplasm. Molecular Function: protein binding. Biological Process: tumor necrosis factor production; I-kappaB kinase/NF-kappaB cascade; T cell activation; interleukin-6 production; interferon-gamma production; mitotic cell cycle; interferon-alpha production