antibody

Rabbit hnRNP C1/2 (Phospho-Ser260) Antibody

MBS001687

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit hnRNP C1/2 (Phospho-Ser260) Antibody

hnRNP C1/2 (Phospho-Ser260)

HNRNPC, HNRPC, Heterogeneous nuclear ribonucleoproteins C1/C2, ROC, hnRNP C1 /hnRNP C2, hnRNP-C1/C2

heterogeneous nuclear ribonucleoproteins C1/C2 isoform a; Heterogeneous nuclear ribonucleoproteins C1/C2; heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein; heterogeneous nuclear ribonucleoprotein C (C1/C2)

hnRNP C1/2

HNRNPC; HNRNPC; C1; C2; HNRNP; HNRPC; SNRPC; HNRPC; hnRNP C1/C2

HNRPC_HUMAN

IgG

Rabbit

Human, Mouse

306

hnRNP C1/2 (Phospho-Ser260) antibody detects endogenous levels of hnRNP C1/2 only when phosphorylated at serine 260.

Rabbit IgG in phosphate buffered saline (without Mg 2+ and Ca 2+ ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Store at -20 degree C/1 year

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

WB: 1:500~1:3000. IHC: 1:50~1:100. ELISA: 1:20000

117190192

NP_001070910.1

NM_001077442.1

P07910

41kDa

Gene Expression Pathway (105937); Processing Of Capped Intron-Containing Pre-mRNA Pathway (160950); Regulation Of Telomerase Pathway (137987); Spliceosome Pathway (125136); Spliceosome Pathway (124832); MRNA Splicing Pathway (105951); MRNA Splicing - Major Pathway (105952); MRNA Processing Pathway (198843)

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described. Protein type: RNA-binding; Spliceosome; RNA splicing. Chromosomal Location of Human Ortholog: 14q11.2. Cellular Component: nucleoplasm; spliceosome; protein complex; membrane; nuclear chromatin; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; nucleosomal DNA binding; mRNA 3 -UTR binding; RNA binding; nucleotide binding; poly(U) binding. Biological Process: nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA splicing; ATP-dependent chromatin remodeling; gene expression

0.05 mL

270 USD

0.1 mL

445