antibody

Rabbit Cyclin A1 Antibody

MBS001316

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Cyclin A1 Antibody

Cyclin A1

cyclin-A1 isoform b; Cyclin-A1; cyclin-A1; cyclin A1

CCNA1; CCNA1

CCNA1_HUMAN

IgG

Rabbit

Human, Mouse, Rat

464

Cyclin A antibody detects endogenous levels of total Cyclin A.

Affinity-chromatography

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

WB: 1:500~1:3000. IHC: 1:50~1:200 . IF: 1:100~1:500. Optimal dilutions/concentrations should be determined by the end user.

Background: CCNA1 May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family; CCNA2 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.

161377468

NP_001104515.1

NM_001111045.1

P78396

53kDa

AMPK Signaling Pathway (198868); APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); C-MYB Transcription Factor Network Pathway (138073); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CCNA1: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor co-regulator; Cancer Testis Antigen (CTA); Cell cycle regulation. Chromosomal Location of Human Ortholog: 13q12.3-q13. Cellular Component: nucleoplasm; microtubule cytoskeleton; cytosol. Molecular Function: protein binding; protein kinase binding. Biological Process: G1/S-specific transcription in mitotic cell cycle; mitosis; male meiosis I; cell division; regulation of G2/M transition of mitotic cell cycle; spermatogenesis; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle

0.05 mL

270 USD

0.1 mL

445