antibody

Rabbit HSP90B (Ab-226) Antibody

MBS001023

0.05 mL

270 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit HSP90B (Ab-226) Antibody

HSP90B (Ab-226)

heat shock protein HSP 90-beta isoform a; Heat shock protein HSP 90-beta; heat shock protein HSP 90-beta; HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; Heat shock 84 kDa

HSP90B

HSP90AB1; HSP90AB1; HSP84; HSPC2; HSPCB; D6S182; HSP90B; HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84

HS90B_HUMAN

Rabbit

Human, mouse, rat

724

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

431822401

NP_001258898.1

NM_001271969.1

P08238

83,264 Da

Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); Immune System Pathway (106386); Inflammasomes Pathway (366166); Innate Immune System Pathway (106387)

This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family. Protein type: Chaperone; Heat shock protein. Chromosomal Location of Human Ortholog: 6p12. Cellular Component: signalosome; nucleoplasm; cell surface; mitochondrion; membrane; basolateral plasma membrane; brush border membrane; apical plasma membrane; cytoplasm; melanosome; inclusion body; cytosol. Molecular Function: protein binding; GTP binding; TPR domain binding; unfolded protein binding; nitric-oxide synthase regulator activity; double-stranded RNA binding; dATP binding; sulfonylurea receptor binding; kinase binding; protein kinase binding; ATP binding. Biological Process: axon guidance; positive regulation of nitric oxide biosynthetic process; positive regulation of cell size; positive regulation of protein import into nucleus, translocation; positive regulation of protein binding; protein folding; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to salt stress; response to unfolded protein; placenta development

0.05 mL

270 USD

0.1 mL

445