product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit CTRO Antibody
catalog :
MBS000713
quantity :
0.05 mL
price :
270 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS000713
products type :
Antibody
products full name :
Rabbit CTRO Antibody
products short name :
CTRO
other names :
citron Rho-interacting kinase isoform 1; Citron Rho-interacting kinase; citron Rho-interacting kinase; serine/threonine-protein kinase 21; citron (rho-interacting, serine/threonine kinase 21); Serine/threonine-protein kinase 21
products gene name :
CTRO
other gene names :
CIT; CIT; CRIK; STK21; CRIK; KIAA0949; STK21; CRIK
uniprot entry name :
CTRO_HUMAN
host :
Rabbit
reactivity :
Human (Identities = 100%, Positives = 100%). Mouse (Identities = 100%, Positives = 100%)
sequence length :
2069
specificity :
CTRO antibody detects endogenous levels of total CTRO protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
concentration :
1 mg/ml
storage stability :
Store at -20 degree C /1 year
tested application :
Immunohistochemistry (IHC), ELISA (EIA)
app notes :
IHC: 1:50~1:100 . IF: 1:100~1:500. ELISA: 1:40000
ncbi gi num :
332801082
ncbi acc num :
NP_001193928.1
ncbi gb acc num :
NM_001206999.1
uniprot acc num :
O14578
ncbi mol weight :
231,431 Da
ncbi pathways :
G13 Signaling Pathway (198800)
ncbi summary :
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
uniprot summary :
CRIK: an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described. Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; DMPK family. Chromosomal Location of Human Ortholog: 12q24. Cellular Component: ruffle; Golgi cisterna; cell soma; membrane; plasma membrane; vacuole; actin cytoskeleton. Molecular Function: protein serine/threonine kinase activity; protein binding; Rho GTPase binding; metal ion binding; SH3 domain binding; ATP binding; PDZ domain binding. Biological Process: positive regulation of cytokinesis; mitosis; mitotic sister chromatid segregation; generation of neurons; regulation of catalytic activity; regulation of actin polymerization and/or depolymerization; dendrite development; cytokinesis; spermatogenesis; negative regulation of dendrite morphogenesis; G2/M transition of mitotic cell cycle; Golgi organization and biogenesis; protein amino acid phosphorylation; mitotic metaphase/anaphase transition
size1 :
0.05 mL
price1 :
270 USD
size2 :
0.1 mL
price2 :
445
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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