Rabbit KNG1 (heavy chain, Cleaved-Lys380) Antibody | MyBioSource MBS000059 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit KNG1 (heavy chain, Cleaved-Lys380) Antibody

catalog :

MBS000059

quantity :

0.05 mL

price :

270 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS000059

products type :

Antibody

products full name :

Rabbit KNG1 (heavy chain, Cleaved-Lys380) Antibody

products short name :

KNG1 (heavy chain, Cleaved-Lys380)

other names :

kininogen-1 isoform 2; Kininogen-1; kininogen-1; HMWK; bradykinin; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor; kininogen 1; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Williams-Fitzgerald-Flaujeac factorCleaved into the following 6 chains:Kininogen-1 heavy chainT-kinin; Alternative name(s):; Ile-Ser-BradykininBradykinin; Alternative name(s):; Kallidin ILysyl-bradykinin; Alternative name(s):; Kallidin II

products gene name :

KNG1

other gene names :

KNG1; KNG1; BK; BDK; KNG; BDK; KNG; HMWK

uniprot entry name :

KNG1_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

427

form :

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

concentration :

1 mg/ml

tested application :

ELISA (EIA), Western Blot (WB)

ncbi gi num :

4504893

ncbi acc num :

NP_000884.1

ncbi gb acc num :

NM_000893.3

uniprot acc num :

P01042

ncbi mol weight :

71,957 Da

ncbi pathways :

ACE Inhibitor Pathway (198763); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); G Alpha (i) Signalling Events Pathway (119550); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020)

ncbi summary :

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

uniprot summary :

KNG1: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting. Defects in KNG1 are the cause of high molecular weight kininogen deficiency (HMWK deficiency). HMWK deficiency is an autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Secreted; Inhibitor; Secreted, signal peptide; Contractile; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 3q27. Cellular Component: extracellular space; plasma membrane; extracellular region. Molecular Function: heparin binding; protein binding; zinc ion binding; cysteine protease inhibitor activity; receptor binding. Biological Process: negative regulation of proteolysis; platelet activation; elevation of cytosolic calcium ion concentration; smooth muscle contraction; platelet degranulation; positive regulation of apoptosis; negative regulation of blood coagulation; negative regulation of cell adhesion; blood coagulation; inflammatory response; vasodilation; blood coagulation, intrinsic pathway. Disease: High Molecular Weight Kininogen Deficiency

size1 :

0.05 mL

price1 :

270 USD

size2 :

0.1 mL

price2 :

445

more info or order :

MyBioSource product webpage