product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit MARCH2 Antibody
catalog :
MBS000058
quantity :
0.05 mL
price :
270 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS000058
products type :
Antibody
products full name :
Rabbit MARCH2 Antibody
products short name :
2-Mar
other names :
E3 ubiquitin-protein ligase MARCH2 isoform 1; E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase MARCH2; RING finger protein 172; membrane-associated RING-CH protein II; membrane-associated RING finger protein 2; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172
products gene name :
2-Mar
other gene names :
MARCH2; MARCH2; RNF172; HSPC240; MARCH-II; RNF172; MARCH-II
uniprot entry name :
MARH2_HUMAN
host :
Rabbit
reactivity :
Human
sequence length :
246
form :
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
concentration :
1 mg/ml
tested application :
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)
ncbi gi num :
53729332
ncbi acc num :
NP_001005415.1
ncbi gb acc num :
NM_001005415.1
uniprot acc num :
Q9P0N8
ncbi mol weight :
26,995 Da
ncbi summary :
MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]
uniprot summary :
MARCH2: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.2.19; Ligase; Ubiquitin ligase; Membrane protein, multi-pass; EC 6.3.2.-; Membrane protein, integral; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; endoplasmic reticulum; integral to membrane; endosome membrane; cytoplasmic vesicle. Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; ligase activity. Biological Process: protein ubiquitination; endocytosis
size1 :
0.05 mL
price1 :
270 USD
size2 :
0.1 mL
price2 :
445
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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