CD184 (CXCR4) Antibody, anti-human, PE-Vio® 770, REAfinity™ | Miltenyi Biotec 130-109-887 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD184 (CXCR4) Antibody, anti-human, PE-Vio® 770, REAfinity™

catalog :

130-109-887

quantity :

30 tests in 300 µL

price :

146,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA649

reactivity :

human

application :

flow cytometry

citations: 5

Reference
Chen Y, Ramjiawan R, Reiberger T, Ng M, Hato T, Huang Y, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology. 2015;61:1591-602 pubmed publisher
Chatterjee S, Behnam Azad B, Nimmagadda S. The intricate role of CXCR4 in cancer. Adv Cancer Res. 2014;124:31-82 pubmed publisher
Ichiyama K, Yokoyama Kumakura S, Tanaka Y, Tanaka R, Hirose K, Bannai K, et al. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc Natl Acad Sci U S A. 2003;100:4185-90 pubmed
Loetscher P, Moser B, Baggiolini M. Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv Immunol. 2000;74:127-80 pubmed
Berger E, Murphy P, Farber J. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol. 1999;17:657-700 pubmed

product information

Catalog Number :

130-109-887

Product Name :

CD184 (CXCR4) Antibody, anti-human, PE-Vio® 770, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

PE-Vio 770

Antigen Modification :

CD184 (CXCR4)

Clone Name :

REA649

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

146,00 USD

Product Description :

Clone REA649 recognizes the human CD184 antigen, a multi-pass membrane protein, also known as C-X-C chemokine receptor type 4 (CXCR4), leukocyte-derived seven transmembrane domain receptor (LESTR), or fusin. CD184 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lymphopoiesis, myelopoiesis, and cardiogenesis. CD184 exclusively interacts with the endogenous ligand CXCL12. Binding of CXCL12 transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Although CXCL12 is the only known chemokine that binds CD184, recent studies suggest that extracellular ubiquitin also acts as an immune modulator through CD184-mediated signaling. CD184 is a coreceptor for HIV entry by promoting Env-mediated fusion of the virus. Additional information: Clone REA649 displays negligible binding to Fc receptors.

CrossReactivity :

cynomolgus monkey (Macaca fascicularis), rhesus monkey (Macaca mulatta), african green monkey (Chlorocebus aethiops), baboon, chimpanzee (Pan troglodytes), sooty mangabey (Cercocebus atys)

ALTnames :

CXCR4, Fusin, LESTR, FB22, HM89, LCR1, LAP-3, NPYRL

Specificity :

human, non-human primate

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.