RORγ (t) Antibody, anti-human/mouse, Vio® B515, REAfinity™ | Miltenyi Biotec 130-108-860 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

RORγ (t) Antibody, anti-human/mouse, Vio® B515, REAfinity™

catalog :

130-108-860

quantity :

30 tests in 300 µL

price :

134,00 USD

clonality :

monoclonal

host :

human

conjugate :

Vio515

clone name :

REA278

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Moretti S, Renga G, Oikonomou V, Galosi C, Pariano M, Iannitti R, et al. A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis. Nat Commun. 2017;8:14017 pubmed publisher
Jin L, Martynowski D, Zheng S, Wada T, Xie W, Li Y. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010;24:923-9 pubmed publisher
Villey I, de Chasseval R, de Villartay J. RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. Eur J Immunol. 1999;29:4072-80 pubmed

product information

Catalog Number :

130-108-860

Product Name :

RORγ (t) Antibody, anti-human/mouse, Vio® B515, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Vio B515

Antigen Modification :

RORγ (t)

Clone Name :

REA278

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

134,00 USD

Product Description :

Clone REA278 recognizes the retinoid-related orphan receptor-γ (RORγ) antigen and the RORγ (t) isoform, which are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed with highest levels in several tissues like muscle, kidney, and liver, whereas RORγ (t) is expressed almost exclusively in immature CD4+CD8+ double-positive thymocytes. RORγ is the possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivator recruitment. It is essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. RORγ (t) negatively regulates expression of Fas ligand and IL-2 production in T cells. It also binds to the TEA promoter and may be part of the pre-TCR activation cascade leading to the maturation of α/β T cells and may participate in the regulation of DNA accessibility in the TCR-Jα locus. Additional information: Clone REA278 displays negligible binding to Fc receptors.

ALTnames :

RORC, NR1F3, RORG, RZR-GAMMA, RZRG, TOR, NR1F3, RORgamma, TOR, Thor

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.