Fetal Hemoglobin Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-108-270 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Fetal Hemoglobin Antibody, anti-human, APC, REAfinity™

catalog :

130-108-270

quantity :

30 tests in 300 µL

price :

128,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA533

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin C, Sebastiani P, et al. Fetal hemoglobin in sickle cell anemia. Blood. 2011;118:19-27 pubmed publisher
Sankaran V, Menne T, Xu J, Akie T, Lettre G, Van Handel B, et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science. 2008;322:1839-42 pubmed publisher

product information

Catalog Number :

130-108-270

Product Name :

Fetal Hemoglobin Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Fetal Hemoglobin

Clone Name :

REA533

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

128,00 USD

Product Description :

Clone REA533 recognizes the human fetal hemoglobin (HbF) antigen, a form of hemoglobin present during fetal development. The hemoglobin molecule is a tetramer composed of two subunits of α-like globin peptide chains and two subunits of the β-like globin peptides, along with heme moieties necessary for this molecule´s oxygen-carrying capacity. When production of the first enucleated definitive erythrocytes commences from stem and progenitor cells in the fetal liver, the predominant β-like globin molecule produced is γ-globin. The γ-globin chains combine with adult α-globin chains into a stable tetramer forming HbF. Shortly after the time of birth there is a switch from predominant expression of HbF to adult hemoglobin (HbA), which is mediated by a transcriptional switch in definitive erythroid progenitors from γ- to β-globin. The synthesis of HbF is normally reduced to very low levels of less than 0.6% of the total hemoglobin in adults. HbF levels may be increased in adults in a number of inherited and acquired disorders. The clinical significance of these conditions with raised HbF relates to their interaction in disorders such as sickle cell disease and β-thalassemia in which raised levels of HbF can lead to considerable amelioration of disease severity. Additional information: Clone REA533 displays negligible binding to Fc receptors.

ALTnames :

HbF, HbF, α2γ2

Specificity :

human

Concentration :

1:10

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.