IRF-8 Antibody, anti-human/mouse, APC, REAfinity™ | Miltenyi Biotec 130-108-196 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

IRF-8 Antibody, anti-human/mouse, APC, REAfinity™

catalog :

130-108-196

quantity :

30 tests in 300 µL

price :

128,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA516

reactivity :

human, mouse

application :

flow cytometry

citations: 2

Reference
Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, et al. The transcription factor IRF8 activates integrin-mediated TGF-Î² signaling and promotes neuroinflammation. Immunity. 2014;40:187-98 pubmed publisher
Hambleton S, Salem S, Bustamante J, Bigley V, Boisson Dupuis S, Azevedo J, et al. IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med. 2011;365:127-38 pubmed publisher

product information

Catalog Number :

130-108-196

Product Name :

IRF-8 Antibody, anti-human/mouse, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

IRF-8

Clone Name :

REA516

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

128,00 USD

Product Description :

Clone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence–binding protein (ICSBP). IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. IRF-8 is expressed at very high levels in mononuclear phagocytes, and regulates granulocyte/macrophage differentiation and dendritic cell (DC) development. Acting in heterodimeric complexes with other transcription factors, IRF-8 also controls the transcriptional response of mature myeloid cells to interferons and Toll-like receptor agonists, a response in which IRF-8 binds and transactivates the promotors of IL12B and NOS2. IRF-8 knockout mice display a loss of CD8a+ lymphoid DCs, CD103+ tissue myeloid DCs, and plasmacytoid DCs. Additional information: Clone REA516 displays negligible binding to Fc receptors.

ALTnames :

IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B

Specificity :

human, mouse

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.