ChemR23 (CMKLR1) Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-107-598 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

ChemR23 (CMKLR1) Antibody, anti-human, PE, REAfinity™

catalog :

130-107-598

quantity :

100 tests in 1 mL

price :

274,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA455

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Bondue B, De Henau O, Luangsay S, Devosse T, de Nadai P, Springael J, et al. The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLoS ONE. 2012;7:e40043 pubmed publisher

product information

Catalog Number :

130-107-598

Product Name :

ChemR23 (CMKLR1) Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

ChemR23 (CMKLR1)

Clone Name :

REA455

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

100 tests in 1 mL

US List Price :

274,00 USD

Product Description :

Clone REA455 recognizes the human G-protein–coupled receptor ChemR23 antigen, a multi-pass membrane protein which is also known as chemokine-like receptor 1 (CMKLR1). ChemR23 is expressed by leukocyte populations such as macrophages, immature myeloid and plasmacytoid dendritic cells, as well as on a subset of natural killer (NK) cells. Its natural ligand, chemerin, is a small protein isolated and identified from human inflammatory fluids which acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of ERK-1/ERK-2 MAP kinases. Chemerin and ChemR23 are involved in the recruitment of NK and dendritic cells (DCs) into tissues in several human inflammatory diseases. They also participate to the regulation of adipocyte metabolism. Additional information: Clone REA455 displays negligible binding to Fc receptors.

ALTnames :

Cmklr1, CHEMERINR, Dez, RVER1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.