Podoplanin Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-107-016 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Podoplanin Antibody, anti-human, APC, REAfinity™

catalog :

130-107-016

quantity :

30 tests in 300 µL

price :

126,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA446

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Herzog B, Fu J, Wilson S, Hess P, Sen A, McDaniel J, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013;502:105-9 pubmed publisher
Astarita J, Acton S, Turley S. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol. 2012;3:283 pubmed publisher
Zimmer G, Oeffner F, von Messling V, Tschernig T, Gröness H, Klenk H, et al. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem J. 1999;341 ( Pt 2):277-84 pubmed

product information

Catalog Number :

130-107-016

Product Name :

Podoplanin Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Podoplanin

Clone Name :

REA446

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

126,00 USD

Product Description :

Clone REA446 recognizes the human podoplanin antigen, a 38–44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. Additional information: Clone REA446 displays negligible binding to Fc receptors.

ALTnames :

PDPN, Aggrus, Aggrus, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, GP36

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.