CD305 (LAIR-1) Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-106-849 product information

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product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD305 (LAIR-1) Antibody, anti-human, PE, REAfinity™

catalog :

130-106-849

quantity :

30 tests in 300 µL

price :

108,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA447

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Perbellini O, Falisi E, Giaretta I, Boscaro E, Novella E, Facco M, et al. Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia. Haematologica. 2014;99:881-7 pubmed publisher
Meyaard L. The inhibitory collagen receptor LAIR-1 (CD305). J Leukoc Biol. 2008;83:799-803 pubmed

product information

Catalog Number :

130-106-849

Product Name :

CD305 (LAIR-1) Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD305 (LAIR-1)

Clone Name :

REA447

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

108,00 USD

Product Description :

Clone REA447 recognizes the human CD305 antigen, a single-pass type I membrane protein which is also known as leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1). CD305 contains a single extracellular immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is structurally related to several other inhibitory Ig superfamily members. CD305 is expressed on almost all immune cells, including NK cells, T cells, B cells, monocytes, monocyte-derived dendritic cells, eosinophils, basophils, and mast cells. Besides being expressed on differentiated peripheral blood cells, the receptor is also present on CD34+ hematopoietic progenitor cells and on the majority of thymocytes. Cross-linking of CD305 on human NK cells delivers a potent inhibitory signal that is capable of inhibiting target cell lysis by resting and activated NK cells. Furthermore, CD305 can inhibit the cytotoxic activity of effector T cells upon CD3 cross-linking or antigen stimulation. In primary B cells, CD305 cross-linking leads to decreased BCR-induced calcium mobilization and down-regulation of Ig and cytokine production. Additional information: Clone REA447 displays negligible binding to Fc receptors.

ALTnames :

hLAIR1, CD305, LAIR-1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.