CD16 antibodies | Miltenyi Biotec 130-106-761 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD16 antibodies

catalog :

130-106-761

quantity :

for 30 tests

clonality :

recombinant

host :

human

conjugate :

FITC

clone name :

REA423

reactivity :

human

application :

flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s2i	Tobin L, Mavinkurve M, Carolan E, Kinlen D, O Brien E, Little M, et al. NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI Insight. 2017;2: pubmed publisher

product information

Item Name :

CD16 antibodies

Catalog Number :

130-106-761

Quantity :

for 30 tests

Target :

CD16

Reactivity :

human, non-human primate

Applications :

Flow Cytometry

Primary / Secondary :

Primary

Host :

human

Conjugate/Tag/Label :

FITC

Format :

Antibodies are supplied in buffer containing stabilizer and 0.05% sodium azide.

Isotype :

recombinant human IgG1

Clone :

REA423

Clonality :

recombinant

Long text :

Clone REA423 recognizes the human CD16 antigen, a single-pass type I membrane protein which is also known as low affinity immunoglobulin gamma Fc region receptor III (FcRIII). CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils. The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone REA423 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes. Additional information: Clone REA423 displays negligible binding to Fc receptors.