BMI-1 Antibody, anti-human, PE, REAfinity™ | Miltenyi Biotec 130-106-736 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

BMI-1 Antibody, anti-human, PE, REAfinity™

catalog :

130-106-736

quantity :

30 tests in 300 µL

price :

94,00 USD

clonality :

monoclonal

host :

human

conjugate :

clone name :

REA438

reactivity :

human

application :

flow cytometry

citations: 3

Reference
Liu S, Dontu G, Mantle I, Patel S, Ahn N, Jackson K, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006;66:6063-71 pubmed
Park I, Morrison S, Clarke M. Bmi1, stem cells, and senescence regulation. J Clin Invest. 2004;113:175-9 pubmed
Park I, Qian D, Kiel M, Becker M, Pihalja M, Weissman I, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5 pubmed

product information

Catalog Number :

130-106-736

Product Name :

BMI-1 Antibody, anti-human, PE, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

Antigen Modification :

BMI-1

Clone Name :

REA438

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

94,00 USD

Product Description :

Clone REA438 recognizes the human B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) antigen, which is also known as polycomb group RING finger protein 4 (PCGF4). BMI-1 is a member of the polycomb group of transcription repressors that was initially identified as an oncogene cooperating with c-myc in a murine model of lymphoma. Both, hematopoietic stem cells (HSCs) and neuronal stem cells, express high levels of BMI-1. It has been shown that BMI-1 is necessary for efficient self-renewing cell divisions of adult HSCs as well as adult peripheral and central nervous system neural stem cells, but that it is less critical for the generation of differentiated progeny. BMI-1 causes neoplastic proliferation when overexpressed in lymphocytes. Additional information: Clone REA438 displays negligible binding to Fc receptors.

ALTnames :

BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.