Galectin-9 Antibody, anti-human, APC, REAfinity™ | Miltenyi Biotec 130-106-523 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

Galectin-9 Antibody, anti-human, APC, REAfinity™

catalog :

130-106-523

quantity :

30 tests in 300 µL

price :

128,00 USD

clonality :

monoclonal

host :

human

conjugate :

APC

clone name :

REA435

reactivity :

human

application :

flow cytometry

citations: 2

Reference
Leitner J, Rieger A, Pickl W, Zlabinger G, Grabmeier Pfistershammer K, Steinberger P. TIM-3 does not act as a receptor for galectin-9. PLoS Pathog. 2013;9:e1003253 pubmed publisher
Golden Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, et al. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013;87:4835-45 pubmed publisher

product information

Catalog Number :

130-106-523

Product Name :

Galectin-9 Antibody, anti-human, APC, REAfinity™

Product Type :

Antibodies

Host Species :

cell line

Clonality :

monoclonal

Conjugation :

APC

Antigen Modification :

Galectin-9

Clone Name :

REA435

Isotype :

recombinant human IgG1

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

128,00 USD

Product Description :

Clone REA435 recognizes the human galectin-9 antigen, a member of the galectin family of carbohydrate-binding proteins, which is also known as ecalectin or tumor antigen HOM-HD-21. The galectin family is characterized by the presence of two or more conserved carbohydrate-recognition domains that bind galactose. Galectin-9 is widely distributed throughout various tissues and circulates at very high levels in the serum. It interacts with various ligands, the best characterized of which is the T cell immunoglobulin mucin 3 (Tim-3) cell surface molecule, widely expressed on innate and adaptive immune cells. Originally described as an eosinophil chemoattractant, Galectin-9 is now known to be an important pleiotropic immune modulator affecting numerous immune cell types. Galectin-9 is thought to be involved in the activation of innate immune responses and the downregulation of Tʜ17 and Tʜ1 responses. It can promote inflammation through triggering proinflammatory cytokine production from monocytes and inducing maturation of macrophages and monocyte-derived dendritic cells. Conversely, Galectin-9 has a major anti-inflammatory role in the induction of apoptosis in activated T cell subsets, as well as in promoting the differentiation of regulatory T cells expressing FoxP3. Galectin-9 is also involved in the apoptosis of tumor cells. Additional information: Clone REA435 displays negligible binding to Fc receptors.

ALTnames :

Lgals9, HUAT, LGALS9A, Gal-9, Ecalectin, HOM-HD-21

Specificity :

human

Concentration :

1:10

Uses :

For research use only

Application Summary :

Intracellular flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.