CD135 (FLT3) Antibody, anti-human, PE | Miltenyi Biotec 130-106-355 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Miltenyi Biotec

product type :

antibody

product name :

CD135 (FLT3) Antibody, anti-human, PE

catalog :

130-106-355

quantity :

30 tests in 300 µL

price :

99,00 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

BV10A4H2

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Leung A, Man C, Kwong Y. FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia. Leukemia. 2013;27:260-8 pubmed publisher

product information

Catalog Number :

130-106-355

Product Name :

CD135 (FLT3) Antibody, anti-human, PE

Product Type :

Antibodies

Host Species :

mouse

Clonality :

monoclonal

Conjugation :

Antigen Modification :

CD135 (FLT3)

Clone Name :

BV10A4H2

Isotype :

mouse IgG1κ

Light Chain :

kappa light chain

Size :

30 tests in 300 µL

US List Price :

99,00 USD

Product Description :

Clone BV10A4H2 recognizes the human CD135 antigen, a single-pass type I membrane protein also known as Fms-like tyrosine kinase receptor 3 (FLT3) or fetal liver kinase-2 (FLK-2). CD135 belongs to the same family as FMS, KIT, and the two genes encoding PDGFRα and β. CD135 is normally expressed by hematopoietic stem and progenitor cells and expression is lost as hematopoietic cells differentiate. Although CD135 expression is usually lost upon HSC differentiation, dendritic cells are an exception, as mature DCs display persistent FLT3 expression. CD135 is also expressed on malignant hematopoietic cells including AML, ALL, and CML-BC. All hematopoietic cells develop from CD135 negative hematopoietic stem cells through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.

ALTnames :

FLT3, FLK-2, STK-1

Specificity :

human

Concentration :

1:11

Uses :

For research use only

Application Summary :

Flow cytometry

Storage :

Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.